Affiliation:
1. Howard Hughes Medical Institute and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Abstract
Stop, No-Go
The decoding of messenger RNA (mRNA) into protein by eukaryotic ribosomes is constantly monitored to prevent errors. As well as mechanisms that detect and degrade messages with premature stop codons, no-go decay (NGD) results in the degradation of mRNA with inhibitory secondary structure or chemical damage.
Shoemaker
et al.
(p.
369
) show that in
Saccharomyces cerevisiae
the protein complex formed between Dom34 and Hbs1 is involved in NGD. The complex acts as a translational “reset button,” recognizing failed translation events and initiating an abortive program that results in the destruction of the stalled mRNA.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
278 articles.
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