CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency-Reference-Cited by-同舟云学术

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

Published:2016-03-11 Issue:6278 Volume:351 Page:1199-1203
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bidinosti Michael¹,Botta Paolo²,Krüttner Sebastian²,Proenca Catia C.¹,Stoehr Natacha¹,Bernhard Mario¹,Fruh Isabelle¹,Mueller Matthias¹,Bonenfant Debora³,Voshol Hans³,Carbone Walter¹,Neal Sarah J.⁴,McTighe Stephanie M.⁴,Roma Guglielmo¹,Dolmetsch Ricardo E.⁴,Porter Jeffrey A.¹,Caroni Pico²,Bouwmeester Tewis¹,Lüthi Andreas²,Galimberti Ivan¹

Affiliation:

1. Developmental Molecular Pathways, Novartis Institutes for Biomedical Research, Basel, Switzerland.

2. Friedrich Miescher Institute, Basel, Switzerland.

3. Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Basel, Switzerland.

4. Neuroscience, Novartis Institutes for Biomedical Research, Cambridge, USA.

Abstract

Signal problems in autism spectrum disorder Autism spectrum disorders have many causes. Bidinosti et al. studied Phelan-McDermid syndrome (PMDS), one of the symptoms of which can be autism (see the Perspective by Burbach). The authors used neurons derived from these patients, as well as from mice, with the culprit gene disrupted and found that a chain of intracellular signals becomes imbalanced. Signaling and behavioral symptoms could be improved by a small-molecule therapeutic that inhibits a key kinase. Science , this issue p. 1199 ; see also p. 1153

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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