MAIT cell activation augments adenovirus vector vaccine immunogenicity-Reference-Cited by-同舟云学术

MAIT cell activation augments adenovirus vector vaccine immunogenicity

Published:2021-01-29 Issue:6528 Volume:371 Page:521-526
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Provine Nicholas M.¹^ORCID,Amini Ali¹^ORCID,Garner Lucy C.¹^ORCID,Spencer Alexandra J.²^ORCID,Dold Christina³,Hutchings Claire⁴^ORCID,Silva Reyes Laura³^ORCID,FitzPatrick Michael E. B.¹,Chinnakannan Senthil⁴,Oguti Blanche³^ORCID,Raymond Meriel³^ORCID,Ulaszewska Marta²^ORCID,Troise Fulvia⁵⁶^ORCID,Sharpe Hannah²^ORCID,Morgan Sophie B.⁷,Hinks Timothy S. C.⁷^ORCID,Lambe Teresa²^ORCID,Capone Stefania⁸^ORCID,Folgori Antonella⁸^ORCID,Barnes Eleanor¹²⁴^ORCID,Rollier Christine S.³^ORCID,Pollard Andrew J.³^ORCID,Klenerman Paul¹⁴^ORCID

Affiliation:

1. Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

2. Jenner Institute, University of Oxford, Oxford, UK.

3. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.

4. Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.

5. Nouscom, SRL, Rome, Italy.

6. Ceinge Biotechnologie Avanzate, Naples, Italy.

7. Respiratory Medicine Unit, Nuffield Department of Medicine – Experimental Medicine, University of Oxford, Oxford, UK.

8. ReiThera, SRL, Rome, Italy.

Abstract

Vaccines get a help-MAIT Mucosal-associated invariant T (MAIT) cells are a T cell subset important for mucosal homeostasis. These cells recognize derivatives of microbiota-derived vitamin B2 precursors but can also be activated by certain cytokines in the context of viral infections. Provine et al. report that a leading adenoviral vector vaccine, ChAdOx1, activated MAIT cells in immunized mice (see the Perspective by Juno and O'Connor). This activation required interferon-α produced by plasmacytoid dendritic cells as well as monocyte-derived interleukin-18 and tumor necrosis factor. MAIT cell activation positively correlated with vaccine-mediated T cell responses in human subjects, and mice deficient in MAIT cells showed impaired CD8 + T cell immunity to target antigens after vaccination. This work suggests an additional pathway that could be exploited to enhance the efficacy of vaccines. Science , this issue p. 521 ; see also p. 460

Funder

Wellcome

Medical Research Council

NIHR Biomedical Research Centre

Oxford-UCB Postdoctoral Fellowship

NIHR Oxford Biomedical Research Centre

Oxford-Celgene Doctoral Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference44 articles.