An ingestible bacterial-electronic system to monitor gastrointestinal health-Reference-Cited by-同舟云学术

An ingestible bacterial-electronic system to monitor gastrointestinal health

Published:2018-05-25 Issue:6391 Volume:360 Page:915-918
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mimee Mark¹²^ORCID,Nadeau Phillip³^ORCID,Hayward Alison⁴⁵^ORCID,Carim Sean²^ORCID,Flanagan Sarah³^ORCID,Jerger Logan²⁶⁷,Collins Joy⁵^ORCID,McDonnell Shane⁵^ORCID,Swartwout Richard³^ORCID,Citorik Robert J.¹²^ORCID,Bulović Vladimir³,Langer Robert⁵⁸^ORCID,Traverso Giovanni⁵⁸⁹^ORCID,Chandrakasan Anantha P.³,Lu Timothy K.²³¹⁰^ORCID

Affiliation:

1. Microbiology Program, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

2. Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.

3. Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

4. Division of Comparative Medicine, MIT, Cambridge, MA 02139, USA.

5. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

6. Division of Pediatric Gastroentrology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, MA 02114, USA.

7. Harvard Medical School, Boston, MA 02115, USA.

8. Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.

9. Division of Gastroenterology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

10. Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.

Abstract

Using bugs in the gut to detect blood Bacteria are environmentally resilient and can be engineered to sense various biomolecules. Mimee et al. combined biosensor bacteria with a miniaturized wireless readout capsule to produce a minimally invasive device capable of in vivo biosensing in harsh, difficult-to-access environments (see the Perspective by Gibson and Burgell). The device successfully measured gastrointestinal bleeding in pigs. Science , this issue p. 915 ; see also p. 856

Funder

National Institutes of Health

Office of Naval Research Global

National Science Foundation

Hong Kong Innovation and Technology Fund

Center for Microbiome Informatics and Therapeutics

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Principles of genetic circuit design