Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals-Reference-Cited by-同舟云学术

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

Published:2017-05-12 Issue:6338 Volume:356 Page:608-616
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Grillo Anthony S.¹^ORCID,SantaMaria Anna M.²^ORCID,Kafina Martin D.³^ORCID,Cioffi Alexander G.²^ORCID,Huston Nicholas C.³,Han Murui⁴^ORCID,Seo Young Ah⁵^ORCID,Yien Yvette Y.³^ORCID,Nardone Christopher²,Menon Archita V.⁴^ORCID,Fan James¹,Svoboda Dillon C.²^ORCID,Anderson Jacob B.¹^ORCID,Hong John D.¹^ORCID,Nicolau Bruno G.¹,Subedi Kiran¹^ORCID,Gewirth Andrew A.¹^ORCID,Wessling-Resnick Marianne⁶^ORCID,Kim Jonghan⁴^ORCID,Paw Barry H.³⁷⁸^ORCID,Burke Martin D.¹²⁹^ORCID

Affiliation:

1. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

2. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

3. Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.

5. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.

6. Department of Genetic and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

7. Division of Hematology-Oncology, Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

8. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

9. Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA.

Abstract

Shipping iron around in small packages Iron plays a crucial role in a wide variety of biological functions, which in turn rely on the proteins that transport the metal in and out of cells. Grillo et al. used a simple lipophilic small molecule that binds iron ions to restore transport in animal models with deficiencies in iron transporters. This cyclic ketol, hinokitiol, was first tested in yeast and then shown to promote gut iron absorption in rats and mice, as well as hemoglobin production in zebrafish. Science , this issue p. 608

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference109 articles.

1. Principles of Selective Ion Transport in Channels and Pumps

2. Two to Tango: Regulation of Mammalian Iron Metabolism

3. Airway acidification initiates host defense abnormalities in cystic fibrosis mice

4. Autism-associated SHANK3 haploinsufficiency causes I h channelopathy in human neurons

5. Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery

Cited by 109 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity;European Journal of Pharmacology;2024-03

2. Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes;British Journal of Haematology;2024-01-22

3. Membrane Transport and Permeation;Pharmaceutics;2024

4. Protective Effects of Hinokitiol on Neuronal Ferroptosis by Activating the Keap1/Nrf2/HO-1 Pathway in Traumatic Brain Injury;Journal of Neurotrauma;2023-12-28

5. At the dawn of novel aromatics: “On the Synthesis of Hinokitiol” by Tetsuo Nozoe <i>et al.</i>;Proceedings of the Japan Academy, Series B;2023-12-11