Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication-Reference-Cited by-同舟云学术

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

Published:2014-10-24 Issue:6208 Volume:346 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Maric Marija¹²,Maculins Timurs²,De Piccoli Giacomo²,Labib Karim¹

Affiliation:

1. MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

2. Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

Abstract

How to stop after copying the genome Replication is highly regulated: Failure to copy any part of the genome or copying parts of it more than once can cause genome instability with potentially disastrous consequences. Maric et al. and Priego Moreno et al. show that the DNA replication machinery, which stably encircles DNA during the duplication process, is actively disassembled once replication is complete (see the Perspective by Bell). The protein ring encircling the DNA is covalently modified, which allows it to be opened and the whole replication complex to be removed from DNA by a special disassembly complex. Science , this issue 10.1126/science.1253596 , p. 477 ; see also p. 418

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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