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From oncogenic mutation to dynamic code

Published:2018-08-31 Issue:6405 Volume:361 Page:844-845
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kolch Walter¹²³,Kiel Christina¹²⁴

Affiliation:

1. Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

2. School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

3. Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

4. Charles Institute, University College Dublin, Belfield, Dublin 4, Ireland.

Abstract

Oncogenic BRAF mutations can distort downstream signaling outcomes

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference15 articles.

1. The stochastic nature of biochemical networks

2. Information Transduction Capacity of Noisy Biochemical Signaling Networks

3. Accurate information transmission through dynamic biochemical signaling networks

4. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

5. Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

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1. Signaling in the crowded cell;Current Opinion in Structural Biology;2021-12

2. A Hill type equation can predict target gene expression driven by p53 pulsing;FEBS Open Bio;2021-05-27

3. PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective;Cancer Research;2020-10-12

4. Cracking the context-specific PI3K signaling code;Science Signaling;2020-01-07

5. Unraveling allosteric landscapes of allosterome with ASD;Nucleic Acids Research;2019-10-29

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