Feedback control of chromosome separation by a midzone Aurora B gradient

Author:

Afonso Olga1,Matos Irina1,Pereira António J.1,Aguiar Paulo12,Lampson Michael A.3,Maiato Helder14

Affiliation:

1. Chromosome Instability and Dynamics Laboratory, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.

2. Center for Mathematics, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.

3. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Cell Division Unit, Department of Experimental Biology, Faculdade de Medicina, Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.

Abstract

Taking a check on chromosome spacing Animal cells divide by mitosis. Chromosomes become condensed and congregate on the mitotic spindle in the center of the cell—the midzone. The spindle then separates sister chromosomes, pulling them to opposite ends of the cell, ready to form new daughter nuclei. Afonso et al. now show that chromosome separation is monitored by the level of midzone-associated Aurora B kinase activity (see the Perspective by Hadders and Lens). This process ensures that daughter nuclei only reassemble after sister chromosomes have successfully separated. Science , this issue p. 332 ; see also p. 265

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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