Genome Sequence of the PCE-Dechlorinating Bacterium Dehalococcoides ethenogenes-Reference-Cited by-同舟云学术

Genome Sequence of the PCE-Dechlorinating Bacterium Dehalococcoides ethenogenes

Published:2005-01-07 Issue:5706 Volume:307 Page:105-108
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Seshadri Rekha¹²³⁴⁵,Adrian Lorenz¹²³⁴⁵,Fouts Derrick E.¹²³⁴⁵,Eisen Jonathan A.¹²³⁴⁵,Phillippy Adam M.¹²³⁴⁵,Methe Barbara A.¹²³⁴⁵,Ward Naomi L.¹²³⁴⁵,Nelson William C.¹²³⁴⁵,Deboy Robert T.¹²³⁴⁵,Khouri Hoda M.¹²³⁴⁵,Kolonay James F.¹²³⁴⁵,Dodson Robert J.¹²³⁴⁵,Daugherty Sean C.¹²³⁴⁵,Brinkac Lauren M.¹²³⁴⁵,Sullivan Steven A.¹²³⁴⁵,Madupu Ramana¹²³⁴⁵,Nelson Karen E.¹²³⁴⁵,Kang Katherine H.¹²³⁴⁵,Impraim Marjorie¹²³⁴⁵,Tran Kevin¹²³⁴⁵,Robinson Jeffrey M.¹²³⁴⁵,Forberger Heather A.¹²³⁴⁵,Fraser Claire M.¹²³⁴⁵,Zinder Stephen H.¹²³⁴⁵,Heidelberg John F.¹²³⁴⁵

Affiliation:

1. The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

2. Fachgebiet Technische Biochemie, Institut fuÌr Biotechnologie, Technische UniversitaÌt Berlin, Seestrasse 13, D-13353 Berlin, Germany.

3. Johns Hopkins University, Charles and 34th Streets, Baltimore, MD 21218, USA.

4. Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA.

5. Departments of Pharmacology and Microbiology and Tropical Medicine, George Washington University School of Medicine, 2300 Eye Street N.W., Washington, DC 20037, USA.

Abstract

Dehalococcoides ethenogenes is the only bacterium known to reductively dechlorinate the groundwater pollutants, tetrachloroethene (PCE) and trichloroethene, to ethene. Its 1,469,720âbase pair chromosome contains large dynamic duplicated regions and integrated elements. Genes encoding 17 putative reductive dehalogenases, nearly all of which were adjacent to genes for transcription regulators, and five hydrogenase complexes were identified. These findings, plus a limited repertoire of other metabolic modes, indicate that D. ethenogenes is highly evolved to utilize halogenated organic compounds and H 2 . Diversification of reductive dehalogenase functions appears to have been mediated by recent genetic exchange and amplification. Genome analysis provides insights into the organism's complex nutrient requirements and suggests that an ancestor was a nitrogen-fixing autotroph.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference36 articles.

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