Behavioral time scale synaptic plasticity underlies CA1 place fields

Author:

Bittner Katie C.1ORCID,Milstein Aaron D.12ORCID,Grienberger Christine1,Romani Sandro1ORCID,Magee Jeffrey C.1ORCID

Affiliation:

1. Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.

2. Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

A different form of synaptic plasticity How do synaptic or other neuronal changes support learning? This subject has been dominated by Hebb's postulate of synaptic change. Although there is strong experimental support for Hebbian plasticity in a number of preparations, alternative ideas have also been developed over the years. Bittner et al. provide in vivo, in vitro, and modeling data to support the view that non-Hebbian plasticity may underlie the formation of hippocampal place fields (see the Perspective by Krupic). Instead of multiple pairings, a single strong Ca 2+ plateau potential in neuronal dendrites paired with spatial inputs may be sufficient to produce place cells. Science , this issue p. 1033 ; see also p. 974

Funder

HHMI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. D. O. Hebb The Organization of Behavior (Wiley 1949).

2. Toward a modern theory of adaptive networks: Expectation and prediction.

3. P. Dayan L. Abbott Theoretical Neuroscience (MIT Press 2001).

4. Synapses and Memory Storage

5. The Spike-Timing Dependence of Plasticity

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