Comparative transcriptomics reveals human-specific cortical features-Reference-Cited by-同舟云学术

Comparative transcriptomics reveals human-specific cortical features

Published:2023-10-13 Issue:6667 Volume:382 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jorstad Nikolas L.¹^ORCID,Song Janet H. T.²³⁴⁵^ORCID,Exposito-Alonso David²³⁴⁵^ORCID,Suresh Hamsini⁶^ORCID,Castro-Pacheco Nathan⁶^ORCID,Krienen Fenna M.⁷^ORCID,Yanny Anna Marie¹,Close Jennie¹^ORCID,Gelfand Emily¹^ORCID,Long Brian¹^ORCID,Seeman Stephanie C.¹^ORCID,Travaglini Kyle J.¹^ORCID,Basu Soumyadeep⁸⁹^ORCID,Beaudin Marc²³⁴⁵^ORCID,Bertagnolli Darren¹^ORCID,Crow Megan⁶¹⁰^ORCID,Ding Song-Lin¹^ORCID,Eggermont Jeroen⁸^ORCID,Glandon Alexandra¹^ORCID,Goldy Jeff¹^ORCID,Kiick Katelyn¹^ORCID,Kroes Thomas⁸^ORCID,McMillen Delissa¹^ORCID,Pham Trangthanh¹^ORCID,Rimorin Christine¹^ORCID,Siletti Kimberly¹¹^ORCID,Somasundaram Saroja¹^ORCID,Tieu Michael¹^ORCID,Torkelson Amy¹^ORCID,Feng Guoping¹²¹³¹⁴,Hopkins William D.¹⁵,Höllt Thomas⁹^ORCID,Keene C. Dirk¹⁶^ORCID,Linnarsson Sten¹¹^ORCID,McCarroll Steven A.⁷¹⁷^ORCID,Lelieveldt Boudewijn P.⁸¹⁸^ORCID,Sherwood Chet C.¹⁹^ORCID,Smith Kimberly¹^ORCID,Walsh Christopher A.²³⁴⁵^ORCID,Dobin Alexander⁶^ORCID,Gillis Jesse²⁰^ORCID,Lein Ed S.¹^ORCID,Hodge Rebecca D.¹^ORCID,Bakken Trygve E.¹^ORCID

Affiliation:

1. Allen Institute for Brain Science, Seattle, WA 98109, USA.

2. Allen Discovery Center for Human Brain Evolution, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

3. Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA 02115, USA.

4. Department of Pediatrics and Neurology, Harvard Medical School, Boston, MA 02115, USA.

5. Howard Hughes Medical Institute, Boston Children’s Hospital, Boston, MA 02115, USA.

6. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

7. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

8. LKEB, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.

9. Computer Graphics and Visualization Group, Delft University of Technology, Delft, Netherlands.

10. Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

11. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

12. McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

13. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

14. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

15. Keeling Center for Comparative Medicine and Research, University of Texas, MD Anderson Cancer Center, Houston, TX 78602, USA.

16. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.

17. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

18. Pattern Recognition and Bioinformatics Group, Delft University of Technology, Delft, Netherlands.

19. Department of Anthropology, The George Washington University, Washington, DC 20037, USA.

20. Department of Physiology, University of Toronto, Toronto, ON, Canada.

Abstract

The cognitive abilities of humans are distinctive among primates, but their molecular and cellular substrates are poorly understood. We used comparative single-nucleus transcriptomics to analyze samples of the middle temporal gyrus (MTG) from adult humans, chimpanzees, gorillas, rhesus macaques, and common marmosets to understand human-specific features of the neocortex. Human, chimpanzee, and gorilla MTG showed highly similar cell-type composition and laminar organization as well as a large shift in proportions of deep-layer intratelencephalic-projecting neurons compared with macaque and marmoset MTG. Microglia, astrocytes, and oligodendrocytes had more-divergent expression across species compared with neurons or oligodendrocyte precursor cells, and neuronal expression diverged more rapidly on the human lineage. Only a few hundred genes showed human-specific patterning, suggesting that relatively few cellular and molecular changes distinctively define adult human cortical structure.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.ade9516

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