Gene regulatory networks controlling vertebrate retinal regeneration-Reference-Cited by-同舟云学术

Gene regulatory networks controlling vertebrate retinal regeneration

Published:2020-11-20 Issue:6519 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hoang Thanh¹^ORCID,Wang Jie²^ORCID,Boyd Patrick³⁴⁵^ORCID,Wang Fang²^ORCID,Santiago Clayton¹^ORCID,Jiang Lizhi¹,Yoo Sooyeon¹^ORCID,Lahne Manuela³⁴⁵^ORCID,Todd Levi J.⁶^ORCID,Jia Meng³⁴⁵^ORCID,Saez Cristian¹^ORCID,Keuthan Casey⁷^ORCID,Palazzo Isabella⁶^ORCID,Squires Natalie⁶^ORCID,Campbell Warren A.⁶^ORCID,Rajaii Fatemeh²^ORCID,Parayil Trisha¹^ORCID,Trinh Vickie¹^ORCID,Kim Dong Won¹,Wang Guohua²^ORCID,Campbell Leah J.³⁴⁵^ORCID,Ash John⁷^ORCID,Fischer Andy J.⁶^ORCID,Hyde David R.³⁴⁵^ORCID,Qian Jiang²^ORCID,Blackshaw Seth¹²⁸⁹¹⁰^ORCID

Affiliation:

1. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.

4. Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.

5. Center for Zebrafish Research, University of Notre Dame, Notre Dame, IN 46556, USA.

6. Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

7. Department of Ophthalmology, University of Florida School of Medicine, Gainesville, FL 32610, USA.

8. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

9. Center for Human Systems Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

10. Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Unlocking retinal regeneration in mice Zebrafish can regenerate damaged retinal tissue, but mice cannot. Hoang et al. found that tracking changes in gene expression and chromatin accessibility upon injury revealed clues as to why retinal glial cells in zebrafish could generate new neurons but the same cell type in mice could not. In zebrafish, activated Müller glial cells shift into a proliferative phase, whereas in mice, a genetic network returns the glial cells to quiescence. A few transcription factors enforce quiescence in the mouse, and disruption of these allowed Müller glia to proliferate and generate new neurons after retinal injury. Science , this issue p. eabb8598

Funder

National Eye Institute

Research to Prevent Blindness

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. Reprogramming Müller Glia to Regenerate Retinal Neurons

2. The Proneural Basic Helix-Loop-Helix Gene Ascl1a Is Required for Retina Regeneration

3. Stimulation of functional neuronal regeneration from Müller glia in adult mice

4. Linking YAP to Müller Glia Quiescence Exit in the Degenerative Retina

5. The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming

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