Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis-Reference-Cited by-同舟云学术

Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis

Published:2015-12-04 Issue:6265 Volume:350 Page:1251-1255
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hanchate Naresh K.¹,Kondoh Kunio¹,Lu Zhonghua¹,Kuang Donghui¹,Ye Xiaolan¹,Qiu Xiaojie²³,Pachter Lior⁴,Trapnell Cole²,Buck Linda B.¹

Affiliation:

1. Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

2. Department of Genome Sciences, University of Washington, Seattle, WA 98115, USA.

3. Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98115, USA.

4. Departments of Mathematics, Molecular and Cell Biology, and Electrical Engineering and Computer Sciences, University of California–Berkeley, Berkeley, CA 94720, USA.

Abstract

Maturation of olfactory neurons The sense of smell depends on neurons in the olfactory epithelium to perceive chemical scents. Each neuron specializes with one receptor. Hanchate et al. now show that the one-for-one relationship is not as simple as thought. As new neurons develop to replenish the olfactory epithelium, they initially express several different alleles of olfactory receptors. Then, as each neuron matures, they specialize to express a single receptor. Science , this issue p. 1251

Funder

NIH

Howard Hughes Medical Institute

Alfred P. Sloan Fellowship

Damon Runyon Cancer Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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