Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures

Abstract

Channels from DNA Artificial transmembrane channels are of interest for applications, such as sensing and modifying cell signaling. Langecker et al. (p. 932 ; see the Perspective by Strano ) used α-hemolysin as a model for creating a nanostructure with DNA origami that, when inserted into a lipid bilayer membrane, acted as a membrane channel. Ion channel responses were similar to those measured for natural ion channels, and channels that protruded further into the membrane exhibited greater gating responses. The channels were used to detect single-DNA molecules.