BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage-Reference-Cited by-同舟云学术

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

Published:1998-08-14 Issue:5379 Volume:281 Page:1009-1012
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gowen Lori C.¹,Avrutskaya Anna V.¹,Latour Anne M.¹,Koller Beverly H.¹,Leadon Steven A.¹

Affiliation:

1. L. C. Gowen, Curriculum in Genetics and Molecular Biology and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. A. V. Avrutskaya and S. A. Leadon, Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. A. M. Latour and B. H. Koller, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

The breast and ovarian cancer susceptibility gene BRCA1 encodes a zinc finger protein of unknown function. Association of the BRCA1 protein with the DNA repair protein Rad51 and changes in the phosphorylation and cellular localization of the protein after exposure to DNA-damaging agents are consistent with a role for BRCA1 in DNA repair. Here, it is shown that mouse embryonic stem cells deficient in BRCA1 are defective in the ability to carry out transcription-coupled repair of oxidative DNA damage, and are hypersensitive to ionizing radiation and hydrogen peroxide. These results suggest that BRCA1 participates, directly or indirectly, in transcription-coupled repair of oxidative DNA damage.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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