Affiliation:
1. Division of Tumor Immunology, Dana-Farber Cancer Institute, and the Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Abstract
Transcription factors of the nuclear factor–κB/rel (NF-κB) family may be important in cell survival by regulating unidentified, anti-apoptotic genes. One such gene that protects cells from apoptosis induced by Fas or tumor necrosis factor type α (TNF),
IEX-
1L, is described here. Its transcription induced by TNF was decreased in cells with defective NF-κB activation, rendering them sensitive to TNF-induced apoptosis, which was abolished by transfection with
IEX-
1L. In support, overexpression of antisense
IEX-
1L partially blocked TNF-induced expression of
IEX
-1L and sensitized normal cells to killing. This study demonstrates a key role of
IEX-
1L in cellular resistance to TNF-induced apoptosis.
Publisher
American Association for the Advancement of Science (AAAS)
Reference27 articles.
1. Beyaert R., Fiers W., FEBS Lett. 340, 9 (1994);
2. Wallach D., Trends Biochem. Sci. 22, 107 (1997).
3. Hsu H., Shu H., Pan M., Goeddel D. V., Cell 84, 299 (1996);
4. Liu Z., Hsu H., Goeddel D. V., Karin M., ibid. 87, 565 (1996).
5. P. A. Baeuerle and D. Baltimore ibid. 87 13 (1996);
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