Structure of the RNA-dependent RNA polymerase from COVID-19 virus-Reference-Cited by-同舟云学术

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Published:2020-05-15 Issue:6492 Volume:368 Page:779-782
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gao Yan¹²^ORCID,Yan Liming¹^ORCID,Huang Yucen¹,Liu Fengjiang²^ORCID,Zhao Yao²^ORCID,Cao Lin³,Wang Tao¹^ORCID,Sun Qianqian²^ORCID,Ming Zhenhua⁴,Zhang Lianqi¹,Ge Ji¹,Zheng Litao¹,Zhang Ying¹,Wang Haofeng²⁵^ORCID,Zhu Yan²,Zhu Chen²,Hu Tianyu²^ORCID,Hua Tian²,Zhang Bing²^ORCID,Yang Xiuna²,Li Jun²^ORCID,Yang Haitao²^ORCID,Liu Zhijie²,Xu Wenqing²,Guddat Luke W.⁶^ORCID,Wang Quan²^ORCID,Lou Zhiyong¹^ORCID,Rao Zihe¹²³⁷^ORCID

Affiliation:

1. Laboratory of Structural Biology, School of Life Sciences, and School of Medicine, Tsinghua University, Beijing, China.

2. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

3. State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Response, College of Life Sciences, and College of Pharmacy, Nankai University, Tianjin, China.

4. State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Life Science and Technology, Guangxi University, Nanning, China.

5. School of Life Sciences, Tianjin University, Tianjin, China.

6. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.

7. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, CAS, Beijing, China.

Abstract

The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al. focused on a complex that plays a key role in the replication and transcription cycle of the virus. They used cryo–electron microscopy to determine a 2.9-angstrom-resolution structure of the RNA-dependent RNA polymerase nsp12, which catalyzes the synthesis of viral RNA, in complex with two cofactors, nsp7 and nsp8. nsp12 is a target for nucleotide analog antiviral inhibitors such as remdesivir, and the structure may provide a basis for designing new antiviral therapeutics. Science , this issue p. 779

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Strategic Priority Research Program of the Chinese Academy of Sciences

National Program on Key Research Project of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

2. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study