Tropism for tuft cells determines immune promotion of norovirus pathogenesis-Reference-Cited by-同舟云学术

Tropism for tuft cells determines immune promotion of norovirus pathogenesis

Published:2018-04-13 Issue:6385 Volume:360 Page:204-208
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wilen Craig B.¹^ORCID,Lee Sanghyun¹^ORCID,Hsieh Leon L.¹^ORCID,Orchard Robert C.¹,Desai Chandni¹^ORCID,Hykes Barry L.¹,McAllaster Michael R.¹,Balce Dale R.¹^ORCID,Feehley Taylor¹,Brestoff Jonathan R.¹^ORCID,Hickey Christina A.¹^ORCID,Yokoyama Christine C.¹,Wang Ya-Ting¹^ORCID,MacDuff Donna A.²^ORCID,Kreamalmayer Darren¹,Howitt Michael R.³^ORCID,Neil Jessica A.⁴^ORCID,Cadwell Ken⁴^ORCID,Allen Paul M.¹,Handley Scott A.¹^ORCID,van Lookeren Campagne Menno⁵,Baldridge Megan T.⁶^ORCID,Virgin Herbert W.¹^ORCID

Affiliation:

1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.

3. Department of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

4. Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.

5. Department of Immunology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

6. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Aiding and abetting norovirus disease Norovirus is highly infectious and usually causes transient, acute disease. In some individuals, norovirus persists and is associated with inflammatory bowel disorders. While investigating the cell tropism for murine norovirus, Wilen et al. discovered that a rare cell type, tuft cells, carrying the CD300lf receptor were the virus's specific target. Tuft cells proliferate in response to the type 2 cytokines interleukin-4 and interleukin-25, which thereby amplify norovirus infection. Moreover, infected tuft cells are resistant to immune clearance. This effect may explain the associated persistent disease symptoms that humans can suffer. Science , this issue p. 204

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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