Mg 2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D

Author:

Chaigne-Delalande Benjamin1,Li Feng-Yen12,O’Connor Geraldine M.3,Lukacs Marshall J.1,Jiang Ping1,Zheng Lixin1,Shatzer Amber4,Biancalana Matthew1,Pittaluga Stefania5,Matthews Helen F.1,Jancel Timothy J.6,Bleesing Jack J.7,Marsh Rebecca A.7,Kuijpers Taco W.8,Nichols Kim E.9,Lucas Carrie L.1,Nagpal Sunil10,Mehmet Huseyin10,Su Helen C.11,Cohen Jeffrey I.3,Uzel Gulbu12,Lenardo Michael J.1

Affiliation:

1. Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Biomedical Sciences Graduate Program, University of California–San Francisco, San Francisco, CA 94143, USA.

3. Cancer and Inflammation Program, Laboratory of Experimental Immunology, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

4. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

5. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

6. Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA.

7. Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, OH 45229, USA.

8. Pediatric Hematology, Immunology and Infectious Diseases, Academic Medical Center, Amsterdam, Netherlands.

9. Division of Oncology The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

10. Respiratory and Immunology Division, Merck Research Laboratories, Boston, MA 021159, USA.

11. Immunological Diseases Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

12. Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Magnesium to the Rescue Individuals with X-linked immunodeficiency with Mg 2+ defect, Epstein-Barr virus (EBV) infection, and neoplasia (XMEN) disease are genetically deficient for expression of MAGT1 , a magnesium transporter. Chaigne-Delalande et al. (p. 186 ) sought to better understand why these individuals are chronically infected with EBV at high viral loads and are susceptible to the development of lymphomas. CD8 + T cells and natural killer cells, which help to keep EBV infection in check, exhibited reduced cytotoxicity owing to their lower expression of the cell surface receptor NKG2D, which triggers cytolysis upon ligation. Magnesium supplementation in vitro and also in two XMEN patients restored levels of free Mg 2+ , increased NKG2D expression, and resulted in reduced amounts of EBV + cells, suggesting that this may be an effective therapeutic approach for XMEN patients.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3