A thalamocortical top-down circuit for associative memory

Abstract

Higher-order thalamus input to the cortex Sensory information can only be used meaningfully in the brain when integrated with and compared with internally generated top-down signals. However, we know little about the brainwide afferents that convey such top-down signals, their information content, and learning-related plasticity. Pardi et al. identified the higher-order thalamus as a major source of top-down input to mouse auditory cortex and investigated a circuit in cortical layer 1 that facilitates plastic changes and flexible responses. These results demonstrate how top-down feedback information can reach cortical areas through a noncortical structure that has received little attention despite its widespread connections with the cortex. Science , this issue p. 844