Molecular phenotyping reveals the identity of Barrett’s esophagus and its malignant transition-Reference-Cited by-同舟云学术

Molecular phenotyping reveals the identity of Barrett’s esophagus and its malignant transition

Published:2021-08-13 Issue:6556 Volume:373 Page:760-767
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nowicki-Osuch Karol¹^ORCID,Zhuang Lizhe¹^ORCID,Jammula Sriganesh²,Bleaney Christopher W.³^ORCID,Mahbubani Krishnaa T.⁴⁵^ORCID,Devonshire Ginny²^ORCID,Katz-Summercorn Annalise¹^ORCID,Eling Nils²⁶^ORCID,Wilbrey-Clark Anna⁷,Madissoon Elo⁷^ORCID,Gamble John⁴⁸,Di Pietro Massimiliano¹^ORCID,O’Donovan Maria¹,Meyer Kerstin B.⁷^ORCID,Saeb-Parsy Kourosh⁴⁸^ORCID,Sharrocks Andrew D.³,Teichmann Sarah A.⁷⁹^ORCID,Marioni John C.²⁶⁷^ORCID,Fitzgerald Rebecca C.¹^ORCID

Affiliation:

1. Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge CB2 0X2, UK.

2. Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.

3. Faculty of Biology, Medicine and Health, Michael Smith Building, Oxford Road, University of Manchester, Manchester, UK.

4. Cambridge Biorepository for Translational Medicine (CBTM), NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

5. Department of Haematology, University of Cambridge, Cambridge, UK.

6. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

7. Wellcome Sanger Institute, Welcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

8. Department of Surgery, University of Cambridge, Cambridge, UK.

9. Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK.

Abstract

Identifying the origin of cancer Many cancers are classified on the basis of the organ or tissue from which they originated. However, identifying the specific cells and conditions that precede tumorigenesis can help us understand and better treat the resulting disease. Nowicki-Osuch et al . used a single-cell approach to investigate the cell of origin for Barrett’s esophagus (BE) and the mechanisms leading to the development of esophageal adenocarcinoma (EAC) (see the Perspective by Geboes and Hoorens). Analyses of healthy human esophageal tissues, mutational lineage tracing, and organoid models revealed that BE originates from the gastric cardia and that EAC arises from undifferentiated BE cells. This analysis provides a map of the transcriptional landscape of the healthy esophagus that can be compared with mouse models of disease. —LMZ

Funder

Katharine Susannah Prichard Writers’ Centre

Chan Zuckerberg Initiative

California Walnut Board

Medical Research Council

Cancer Research UK

Academy of Korean Studies

Brunei Research Council

NIHR Cambridge BRC

Wellcome Trust Grant

Publisher

American Association for the Advancement of Science (AAAS)