The coding and long noncoding single-cell atlas of the developing human fetal striatum

Author:

Bocchi Vittoria Dickinson12ORCID,Conforti Paola12ORCID,Vezzoli Elena12ORCID,Besusso Dario12ORCID,Cappadona Claudio12ORCID,Lischetti Tiziana12ORCID,Galimberti Maura12,Ranzani Valeria2ORCID,Bonnal Raoul J. P.2ORCID,De Simone Marco2,Rossetti Grazisa2ORCID,He Xiaoling3,Kamimoto Kenji456ORCID,Espuny-Camacho Ira12ORCID,Faedo Andrea12ORCID,Gervasoni Federica27ORCID,Vuono Romina3,Morris Samantha A.456ORCID,Chen Jian8ORCID,Felsenfeld Dan8ORCID,Pavesi Giulio1ORCID,Barker Roger A.3ORCID,Pagani Massimiliano27ORCID,Cattaneo Elena12ORCID

Affiliation:

1. Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.

2. INGM, Istituto Nazionale Genetica Molecolare, Milan, Italy.

3. WT-MRC Cambridge Stem Cell Institute and Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.

4. Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

6. Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

7. Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Milan, Italy.

8. CHDI Management/CHDI Foundation, New York, NY, USA.

Abstract

Development of the human striatum revealed Deep in the brain, the striatum receives and coordinates inputs from other parts of the brain. Bocchi et al. surveyed molecular features as the striatum develops in the human brain. Single-cell surveys of long intergenic noncoding RNAs revealed a progenitor for medium spiny neurons and provide insight into evolutionary divergence of this critical part of the brain. Science , this issue p. eabf5759

Funder

CHDI Foundation

Wellcome

Colorado College

FP7 Coordination of Non-Community Research Programmes

Majlis Keselamatan Negara Malaysia

NIHR funding

WT-MRC cambridge stem cell institute

NeurostemcellRepair

NSC-Reconstruct

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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