Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”-Reference-Cited by-同舟云学术

Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”

Published:2011-05-20 Issue:6032 Volume:332 Page:917-917
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tan Chris Soon Heng¹²³,Schoof Erwin M.⁴⁵,Creixell Pau⁴⁵,Pasculescu Adrian¹,Lim Wendell A.⁶,Pawson Tony¹²,Bader Gary D.¹²³,Linding Rune⁴⁵

Affiliation:

1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

2. Department of Molecular Genetics, University of Toronto, Toronto, Canada.

3. The Donnelly Centre, University of Toronto, Toronto, Canada.

4. The Institute of Cancer Research (ICR), London, UK.

5. Cellular Signal Integration Group (C-SIG), Center for Biological Sequence Analysis (CBS), Department of Systems Biology, Technical University of Denmark (DTU), DK-2800 Lyngby, Denmark.

6. Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, USA.

Abstract

Su et al . claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference16 articles.

1. Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

2. A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinases

3. Positive Selection of Tyrosine Loss in Metazoan Evolution

4. Systematic Discovery of In Vivo Phosphorylation Networks

5. Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”

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