Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation-Reference-Cited by-同舟云学术

Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation

Published:2002-07-26 Issue:5581 Volume:297 Page:573-578
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mahdavi Jafar¹,Sondén Berit¹,Hurtig Marina¹,Olfat Farzad O.¹²,Forsberg Lina¹,Roche Niamh³,Ångström Jonas³,Larsson Thomas³,Teneberg Susann³,Karlsson Karl-Anders³,Altraja Siiri⁴,Wadström Torkel⁵,Kersulyte Dangeruta⁶,Berg Douglas E.⁶,Dubois Andre⁷,Petersson Christoffer⁸,Magnusson Karl-Eric⁸,Norberg Thomas⁹,Lindh Frank¹⁰,Lundskog Bertil B.¹¹,Arnqvist Anna¹¹²,Hammarström Lennart¹³,Borén Thomas¹

Affiliation:

1. Department of Odontology/Oral Microbiology, Umeå University, SE-901 87 Umeå, Sweden.

2. The Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden.

3. Institute of Medical Biochemistry, Göteborg University, Box 440, SE-405 30 Göteborg, Sweden.

4. Institute of Molecular and Cell Biology, Tartu University, EE-51010 Tartu, Estonia.

5. Department of Infectious Diseases and Medical Microbiology, Lund University, SE-223 62 Lund, Sweden.

6. Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA.

7. Laboratory of Gastrointestinal and Liver Studies, Department of Medicine, USUHS, Bethesda, MD 20814–4799, USA.

8. Department of Molecular and Clinical Medicine, Division of Medical Microbiology, Linköping University, SE-581 85 Linköping, Sweden.

9. Department of Chemistry, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.

10. IsoSep AB, Dalkärrsv. 11, SE-146 36 Tullinge, Sweden.

11. Department of Medical Biosciences/Clinical Cytology, Umeå University, SE-901 87 Umeå, Sweden.

12. Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden.

13. Center for Biotechnology, Karolinska Institute, Novum, SE-141 57 Huddinge, Sweden.

Abstract

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H . pylori and show that H . pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid–binding adhesin (SabA) was isolated with the “retagging” method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H . pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H . pylori infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. T. L. Cover et al. in Principles of Bacterial Pathogenesis E. A. Groisman Ed. (Academic Press New York 2001) pp. 509–558.

2. M. Gerhard et al. in Helicobacter pylori: Molecular and Cellular Biology S. Suerbaum and M. Achtman Eds. (Horizon Scientific Press Norfolk UK 2001) chap. 12.

3. Attachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens

4. Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging

5. M. Hurtig T. Borén in preparation.

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