Dynamic Nuclear Actin Assembly by Arp2/3 Complex and a Baculovirus WASP-Like Protein-Reference-Cited by-同舟云学术

Dynamic Nuclear Actin Assembly by Arp2/3 Complex and a Baculovirus WASP-Like Protein

Published:2006-10-20 Issue:5798 Volume:314 Page:464-467
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Goley Erin D.¹²,Ohkawa Taro¹²,Mancuso Joel¹²,Woodruff Jeffrey B.¹²,D'Alessio Joseph A.¹²,Cande W. Zacheus¹²,Volkman Loy E.¹²,Welch Matthew D.¹²

Affiliation:

1. Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

2. Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.

Abstract

Diverse bacterial and viral pathogens induce actin polymerization in the cytoplasm of host cells to facilitate infection. Here, we describe a pathogenic mechanism for promoting dynamic actin assembly in the nucleus to enable viral replication. The baculovirus Autographa californica multiple nucleopolyhedrovirus induced nuclear actin polymerization by translocating the host actin-nucleating Arp2/3 complex into the nucleus, where it was activated by p78/83, a viral Wiskott-Aldrich syndrome protein (WASP)–like protein. Nuclear actin assembly by p78/83 and Arp2/3 complex was essential for viral progeny production. Recompartmentalizing dynamic host actin may represent a conserved mode of pathogenesis and reflect viral manipulation of normal functions of nuclear actin.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. Baculovirus as versatile vectors for protein expression in insect and mammalian cells

2. C. A. Charlton, L. E. Volkman, J. Virol.65, 1219 (1991).

3. C. A. Charlton, L. E. Volkman, Virology197, 245 (1993).

4. T. Ohkawa, A. R. Rowe, L. E. Volkman, J. Virol.76, 12281 (2002).

5. L. E. Volkman, P. A. Goldsmith, R. T. Hess, Virology156, 32 (1987).

Cited by 154 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Multifaceted interactions between host ESCRT-III and budded virus-related proteins involved in entry and egress of the baculovirus Autographa californica multiple nucleopolyhedrovirus;Journal of Virology;2024-02-20

2. Transcriptomics and interactomics during the primary infection of an SfNPV baculovirus on Spodoptera frugiperda larvae;Frontiers in Cellular and Infection Microbiology;2023-11-21

3. Baculovirus Actin Rearrangement-Inducing Factor 1 Can Remodel the Mammalian Actin Cytoskeleton;Microbiology Spectrum;2023-04-13

4. The Mechanisms of Silkworm Resistance to the Baculovirus and Antiviral Breeding;Annual Review of Entomology;2023-01-23

5. Assembly and transport of filovirus nucleocapsids;PLOS Pathogens;2022-07-28