Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

Author:

Sonnenburg Justin L.123,Xu Jian123,Leip Douglas D.123,Chen Chien-Huan123,Westover Benjamin P.123,Weatherford Jeremy123,Buhler Jeremy D.123,Gordon Jeffrey I.123

Affiliation:

1. Center for Genome Sciences, Washington University, St. Louis, MO 63108, USA.

2. Department of Molecular Biology and Pharmacology, Washington University, St. Louis, MO 63108, USA.

3. Department of Computer Science and Engineering, Washington University, St. Louis, MO 63108, USA.

Abstract

Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron , followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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