Landscape of Somatic Retrotransposition in Human Cancers-Reference-Cited by-同舟云学术

Landscape of Somatic Retrotransposition in Human Cancers

Published:2012-08-24 Issue:6097 Volume:337 Page:967-971
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lee Eunjung¹²,Iskow Rebecca³,Yang Lixing¹,Gokcumen Omer³,Haseley Psalm¹²,Luquette Lovelace J.¹,Lohr Jens G.⁴⁵,Harris Christopher C.⁶,Ding Li⁶,Wilson Richard K.⁶,Wheeler David A.⁷,Gibbs Richard A.⁷,Kucherlapati Raju²⁸,Lee Charles³,Kharchenko Peter V.¹⁹,Park Peter J.¹²⁹,

Affiliation:

1. Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

2. Division of Genetics, Brigham and Women’s Hospital, Boston, MA 02115, USA.

3. Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115, USA.

4. The Eli and Edythe Broad Institute, Cambridge, MA 02412, USA.

5. Dana-Farber Cancer Institute, Boston, MA 02115, USA.

6. The Genome Institute, Washington University, School of Medicine, St. Louis, MO 63108, USA.

7. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.

8. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

9. Informatics Program, Children’s Hospital, Boston, MA 02115, USA.

Abstract

Movement in the Cancer Genome Transposable elements are genetic sequences that can replicate and move within the genome. The factors that make an element mobile are unknown but are generally considered rare in mammals. Lee et al. (p. 967 , published online 28 June) analyzed five cancer types occurring among several individuals and found that three types of epithelial tumors exhibited high rates of element movement relative to brain and blood cancers. Furthermore, these somatically acquired, tumor-specific elements targeted genes in colorectal cancer that, when disrupted, impact gene expression and thus may be a factor in the progression of the cancers.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

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