Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics-Reference-Cited by-同舟云学术

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Published:2018-01-12 Issue:6372 Volume:359 Page:191-199
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cowell Annie N.¹^ORCID,Istvan Eva S.²^ORCID,Lukens Amanda K.³⁴^ORCID,Gomez-Lorenzo Maria G.⁵^ORCID,Vanaerschot Manu⁶^ORCID,Sakata-Kato Tomoyo³,Flannery Erika L.¹,Magistrado Pamela³,Owen Edward⁷,Abraham Matthew¹^ORCID,LaMonte Gregory¹,Painter Heather J.⁷,Williams Roy M.¹^ORCID,Franco Virginia⁵,Linares Maria⁵^ORCID,Arriaga Ignacio⁵,Bopp Selina³^ORCID,Corey Victoria C.¹,Gnädig Nina F.⁶^ORCID,Coburn-Flynn Olivia⁶,Reimer Christin¹,Gupta Purva¹,Murithi James M.⁶^ORCID,Moura Pedro A.⁶,Fuchs Olivia¹^ORCID,Sasaki Erika¹^ORCID,Kim Sang W.¹,Teng Christine H.¹,Wang Lawrence T.¹,Akidil Aslı⁸,Adjalley Sophie⁸,Willis Paul A.⁹,Siegel Dionicio¹⁰,Tanaseichuk Olga¹¹^ORCID,Zhong Yang¹¹,Zhou Yingyao¹¹,Llinás Manuel⁷^ORCID,Ottilie Sabine¹,Gamo Francisco-Javier⁵,Lee Marcus C. S.⁶⁸^ORCID,Goldberg Daniel E.²^ORCID,Fidock David A.⁶¹²^ORCID,Wirth Dyann F.³⁴^ORCID,Winzeler Elizabeth A.¹¹⁰^ORCID

Affiliation:

1. School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.

2. Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.

4. Infectious Disease Program, The Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.

5. Tres Cantos Medicines Development Campus, Malaria Discovery Performance Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain.

6. Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

7. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.

8. Malaria Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

9. Medicines for Malaria Venture, Post Office Box 1826, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.

10. Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA.

11. Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA.

12. Division of Infectious Diseases, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Abstract

Dissecting Plasmodium drug resistance Malaria is a deadly disease with no effective vaccine. Physicians thus depend on antimalarial drugs to save lives, but such compounds are often rendered ineffective when parasites evolve resistance. Cowell et al. systematically studied patterns of Plasmodium falciparum genome evolution by analyzing the sequences of clones that were resistant to diverse antimalarial compounds across the P. falciparum life cycle (see the Perspective by Carlton). The findings identify hitherto unrecognized drug targets and drug-resistance genes, as well as additional alleles in known drug-resistance genes. Science , this issue p. 191 ; see also p. 159

Funder

National Institutes of Health

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference93 articles.

1. Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

2. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria