Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes-Reference-Cited by-同舟云学术

Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes

Published:2009-07-17 Issue:5938 Volume:325 Page:318-321
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Briggs Adrian W.¹,Good Jeffrey M.¹,Green Richard E.¹,Krause Johannes¹,Maricic Tomislav¹,Stenzel Udo¹,Lalueza-Fox Carles²,Rudan Pavao³,Brajković Dejana⁴,Kućan Željko³,Gušić Ivan³,Schmitz Ralf⁵⁶,Doronichev Vladimir B.⁷,Golovanova Liubov V.⁷,de la Rasilla Marco⁸,Fortea Javier⁸,Rosas Antonio⁹,Pääbo Svante¹

Affiliation:

1. Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.

2. Institute of Evolutionary Biology, Consejo Superior de Investigaciones Científicas, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

3. Croatian Academy of Sciences and Arts, Zrinski trg 11, HR-10000 Zagreb, Croatia.

4. Croatian Academy of Sciences and Arts, Institute for Quaternary Paleontology and Geology, Ante Kovačića 5, HR-10000 Zagreb, Croatia.

5. Landschaftsverband Rheinland Landesmuseum, D-53115 Bonn, Germany.

6. Department of Early Prehistory and Quaternary Ecology, University of Tübingen, Germany.

7. Laboratory of Prehistory, St. Petersburg, Russia.

8. Área de Prehistoria Departamento de Historia Universidad de Oviedo, Oviedo, Spain.

9. Departamento de Paleobiología, Museo Nacional de Ciencias Naturales, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

Abstract

Economic Ancient DNA Sequencing Analysis of ancient DNA is often limited by the availability of ancient material for sequencing. Briggs et al. (p. 318 ; see the news story by Pennisi ) describe a method of ancient DNA sequence retrieval that greatly reduces shotgun sequencing costs while avoiding the many difficulties associated with direct PCR-based approaches. They generated five complete and one near-complete Neandertal mitochondrial DNA genomes, which would have been economically impossible with a simple shotgun approach. Analysis of these genomes shows that Neandertal populations had a much smaller effective population size than modern humans or great apes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. Neandertal Genetic Diversity: A Fresh Look from Old Samples

2. Neanderthals in central Asia and Siberia

3. No Evidence of Neandertal mtDNA Contribution to Early Modern Humans

4. Genetic Analyses from Ancient DNA

5. A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput Sequencing

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