Regulation of the Germinal Center Response by MicroRNA-155-Reference-Cited by-同舟云学术

Regulation of the Germinal Center Response by MicroRNA-155

Published:2007-04-27 Issue:5824 Volume:316 Page:604-608
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Thai To-Ha¹²³⁴⁵,Calado Dinis Pedro¹²³⁴⁵,Casola Stefano¹²³⁴⁵,Ansel K. Mark¹²³⁴⁵,Xiao Changchun¹²³⁴⁵,Xue Yingzi¹²³⁴⁵,Murphy Andrew¹²³⁴⁵,Frendewey David¹²³⁴⁵,Valenzuela David¹²³⁴⁵,Kutok Jeffery L.¹²³⁴⁵,Schmidt-Supprian Marc¹²³⁴⁵,Rajewsky Nikolaus¹²³⁴⁵,Yancopoulos George¹²³⁴⁵,Rao Anjana¹²³⁴⁵,Rajewsky Klaus¹²³⁴⁵

Affiliation:

1. CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA.

2. IFOM–The FIRC Institute for Molecular Oncology, Milano, Via Adamello 16 Milan 20139, Italy.

3. Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

4. Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

5. Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, D-13125 Berlin, Germany.

Abstract

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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