Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Author:

Scheid Johannes F.12,Mouquet Hugo1,Ueberheide Beatrix3,Diskin Ron4,Klein Florian1,Oliveira Thiago Y. K.1,Pietzsch John15,Fenyo David3,Abadir Alexander1,Velinzon Klara1,Hurley Arlene6,Myung Sunnie3,Boulad Farid7,Poignard Pascal89,Burton Dennis R.810,Pereyra Florencia1011,Ho David D.12,Walker Bruce D.101112,Seaman Michael S.13,Bjorkman Pamela J.412,Chait Brian T.3,Nussenzweig Michel C.112

Affiliation:

1. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

2. Charité Universitätsmedizin, D-10117 Berlin, Germany.

3. Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA.

4. Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

5. Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, D14195 Berlin, Germany.

6. Rockefeller University Hospital, The Rockefeller University, New York, NY10065, USA.

7. Bone Marrow Transplant Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

8. Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

9. International AIDS Vaccine Initiative, New York, NY 10028, USA.

10. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA.

11. Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

12. Howard Hughes Medical Institute.

13. Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Abstract

Anti-HIV broadly neutralizing antibodies with similar specificities and modes of binding were found in multiple HIV-infected individuals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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