Soft, bioresorbable coolers for reversible conduction block of peripheral nerves

Author:

Reeder Jonathan T.123ORCID,Xie Zhaoqian45ORCID,Yang Quansan36ORCID,Seo Min-Ho237ORCID,Yan Ying8,Deng Yujun9ORCID,Jinkins Katherine R.3ORCID,Krishnan Siddharth R.23ORCID,Liu Claire310ORCID,McKay Shannon10,Patnaude Emily10,Johnson Alexandra10ORCID,Zhao Zichen45ORCID,Kim Moon Joo11ORCID,Xu Yameng12,Huang Ivy23ORCID,Avila Raudel6,Felicelli Christopher13,Ray Emily14,Guo Xu45,Ray Wilson Z.814,Huang Yonggang23615ORCID,MacEwan Matthew R.814ORCID,Rogers John A.2361016ORCID

Affiliation:

1. Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.

2. Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.

3. Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.

4. State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, China.

5. Ningbo Institute of Dalian University of Technology, Ningbo, China.

6. Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA.

7. School of Biomedical Convergence Engineering, College of Information and Biomedical Engineering, Pusan National University, Busan, Republic of Korea.

8. Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.

9. State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai, China.

10. Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

11. Department of Chemical Engineering, Northwestern University, Evanston, IL, USA.

12. The Institute of Materials Science and Engineering, Washington University, St. Louis, MO, USA.

13. Department of Pathology, Northwestern University, Evanston, IL, USA.

14. Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.

15. Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.

16. Department of Chemistry, Northwestern University, Evanston, IL, USA.

Abstract

Implantable devices capable of targeted and reversible blocking of peripheral nerve activity may provide alternatives to opioids for treating pain. Local cooling represents an attractive means for on-demand elimination of pain signals, but traditional technologies are limited by rigid, bulky form factors; imprecise cooling; and requirements for extraction surgeries. Here, we introduce soft, bioresorbable, microfluidic devices that enable delivery of focused, minimally invasive cooling power at arbitrary depths in living tissues with real-time temperature feedback control. Construction with water-soluble, biocompatible materials leads to dissolution and bioresorption as a mechanism to eliminate unnecessary device load and risk to the patient without additional surgeries. Multiweek in vivo trials demonstrate the ability to rapidly and precisely cool peripheral nerves to provide local, on-demand analgesia in rat models for neuropathic pain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

1. Chronic Opioid Use After Surgery

2. Neuromodulation Management of Chronic Neuropathic Pain in the Central Nervous System

3. A review of the bioelectronic implications of stimulation of the peripheral nervous system for chronic pain conditions

4. Pain Mechanisms: A New Theory

5. M. J. Cousins D. B. Carr T. T. Horlocker P. O. Bridenbaugh Eds. Cousins & Bridenbaugh’s Neural Blockade in Clinical Anesthesia and Pain Medicine (Lippincott Williams & Wilkins 2009).

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