Affiliation:
1. Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84103, USA.
Abstract
Hedgehog, Flatworms, and Regeneration
The Hedgehog (Hh) signaling pathway plays pivotal roles during embryonic development, post-embryonic tissue maintenance, and disease. In spite of having at its core a collection of highly conserved components, the Hh pathway displays unusual differences in signal transduction mechanisms among flies, fish, and mammals. Using planarians (nonparasitic flatworms),
Rink
et al.
(p.
1406
, published online 22 October) report a key role for Hh signaling during adult regeneration and provide evidence that the perplexing diversity of transduction mechanisms may have arisen from animal-specific losses of an ancestral association between cilia and Hh signaling.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
210 articles.
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