Dengue viruses cluster antigenically but not as discrete serotypes

Author:

Katzelnick Leah C.1234,Fonville Judith M.125,Gromowski Gregory D.3,Arriaga Jose Bustos3,Green Angela4,James Sarah L.12,Lau Louis4,Montoya Magelda4,Wang Chunling4,VanBlargan Laura A.3,Russell Colin A.6,Thu Hlaing Myat7,Pierson Theodore C.3,Buchy Philippe8,Aaskov John G.910,Muñoz-Jordán Jorge L.11,Vasilakis Nikos121314,Gibbons Robert V.15,Tesh Robert B.121314,Osterhaus Albert D.M.E.5,Fouchier Ron A.M.5,Durbin Anna16,Simmons Cameron P.171819,Holmes Edward C.20,Harris Eva4,Whitehead Stephen S.3,Smith Derek J.125

Affiliation:

1. Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

2. World Health Organization (WHO) Collaborating Center for Modeling, Evolution, and Control of Emerging Infectious Diseases, Cambridge CB2 3EJ, UK.

3. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.

5. Department of Viroscience, Erasmus MC, Rotterdam 3015 GE, Netherlands.

6. Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.

7. Department of Medical Research, Ziwaka Road, Yangon, Myanmar.

8. Institut Pasteur in Cambodia, Réseau International des Instituts Pasteur, Phnom Penh 12201, Cambodia.

9. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4001, Australia.

10. Australian Army Malaria Institute, Brisbane 4051, Australia.

11. Dengue Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan 00971, Puerto Rico.

12. Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.

13. Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.

14. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.

15. Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.

16. Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

17. Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.

18. Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK.

19. Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia.

20. Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney 2006, Australia.

Abstract

The devil in the dengue details Along with their mosquito vectors, dengue viruses are spreading worldwide to infect millions of people. For a few, subsequent infection results in lethal hemorrhagic disease. Katzelnick et al. used antibody-binding data to map structural divergence and antigenic variation among dengue viruses. Comparing results in monkeys and humans, the viruses approximately clustered into the four known groups. However, the four virus groups showed as much antigenic distance within a group as between groups. This finding helps explain why immune responses to dengue are highly variable, and it has complex implications for epidemiology, disease, and vaccine deployment. Science , this issue p. 1338

Funder

U.S. NIH

NIH

National Institute of Allergy and Infectious Diseases (NIAID)

Bill and Melinda Gates Foundation

Human Frontier Science Program (HFSP)

European Union (EU) FP7

Medical Research Council

National Health and Medical Research Council

Instituto Carlos Slim de la Salud

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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