The Spatial and Temporal Origin of Chandelier Cells in Mouse Neocortex

Abstract

Building Cross Connectivity Chandelier cells innervate the initial segment of axons from pyramidal neurons and are thus placed to regulate pyramidal cell circuits in the brain. Chandelier cells of mice are marked by expression of the NKX2.1 transcription factor. Taniguchi et al. (p. 70 , published online 22 November) followed the development of these neurons and found that chandelier cells originate from the ventral germinal zone. The nascent cells migrate and integrate with cortical neurons following specific developmental pathways.