Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells-Reference-Cited by-同舟云学术

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

Published:2010-09-10 Issue:5997 Volume:329 Page:1345-1348
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Boitano Anthony E.¹²,Wang Jian¹,Romeo Russell²,Bouchez Laure C.¹,Parker Albert E.²,Sutton Sue E.²,Walker John R.²,Flaveny Colin A.³,Perdew Gary H.³,Denison Michael S.⁴,Schultz Peter G.¹,Cooke Michael P.²

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

3. The Pennsylvania State University, University Park, PA 16803, USA.

4. University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.

Abstract

Stem Cell Expansion The ability to expand hematopoietic stem cells (HSCs) during ex-vivo culture has been an important goal for over 20 years. Using a high-throughput chemical screen, Boitano et al. (p. 1345 , published online 5 August; see the Perspective by

Sauvageau and Humphries

) found that a purine derivative, StemRegenin1 (SR1), promoted the expansion of human HSCs. Treatment of HSCs with SR1 (which blocked the activity of the aryl hydrocarbon receptor) led to the expansion of CD34 + cells and a 12 to 17-fold increase in the number of HSCs that engraft immune deficient mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. Stem Cells: A Revolution in Therapeutics—Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies

2. Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application

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5. Expanding the role of umbilical cord blood transplantation

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