Cellular Basis of Itch Sensation

Author:

Sun Yan-Gang1,Zhao Zhong-Qiu1,Meng Xiu-Li12,Yin Jun1,Liu Xian-Yu1,Chen Zhou-Feng1

Affiliation:

1. Departments of Anesthesiology, Psychiatry, and Developmental Biology, Washington University School of Medicine Pain Center, St. Louis, MO 63110, USA.

2. Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, P.R. China.

Abstract

A Separate System for Itch Processing It has been a long-standing question if itch is a subquality of pain involving the same neuronal elements or if distinct, so-called labeled lines exist in the nervous system for both sensations. To address this question directly, Sun et al. (p. 1531 , published online 6 August) destroyed neurons in the superficial spinal dorsal horn that express the gastrin-releasing peptide receptor. This receptor is known to be involved in mediating itch but not pain sensations. In various animal models, ablation of gastrin-releasing peptide receptor-expressing spinal dorsal horn neurons reduced itch without changing pain perception. Thus, itch and pain indeed appear to be mediated by distinct labeled lines in the central nervous system.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

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4. von Frey M., Arch Neerland. Physiol. 7, 142 (1922).

5. The neurobiology of itch

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