Affiliation:
1. National Cancer Institute, Bethesda, MD 20892, USA.
Abstract
The nongenetic roles of the nucleus
The eukaryotic cell nucleus provides a home for the genetic material and accessory proteins. As a physical entity, the nucleus also plays an important role in cell dynamics. Bustin and Misteli Review the impacts that the nucleus can have as a nongenetic force. For example, compacted DNA and the nuclear membrane affect nuclear morphology, the cellular response to mechanical force, cell migration, and cell signaling. Chromatin is not only affected by physical forces in cells but participates in a crosstalk of signaling inside cells.
Science
, this issue p.
10.1126/science.aad6933
Funder
NIH Intramural Research Program
National Cancer Institute
Center for Cancer Research
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
99 articles.
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