The Immunological Synapse Balances T Cell Receptor Signaling and Degradation-Reference-Cited by-同舟云学术

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Published:2003-11-14 Issue:5648 Volume:302 Page:1218-1222
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lee Kyeong-Hee¹²³⁴⁵,Dinner Aaron R.¹²³⁴⁵,Tu Chun¹²³⁴⁵,Campi Gabriele¹²³⁴⁵,Raychaudhuri Subhadip¹²³⁴⁵,Varma Rajat¹²³⁴⁵,Sims Tasha N.¹²³⁴⁵,Burack W. Richard¹²³⁴⁵,Wu Hui¹²³⁴⁵,Wang Julia¹²³⁴⁵,Kanagawa Osami¹²³⁴⁵,Markiewicz Mary¹²³⁴⁵,Allen Paul M.¹²³⁴⁵,Dustin Michael L.¹²³⁴⁵,Chakraborty Arup K.¹²³⁴⁵,Shaw Andrey S.¹²³⁴⁵

Affiliation:

1. Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA.

2. Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA.

3. Department of Chemistry, University of California, Berkeley, CA 94720, USA.

4. Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA.

5. Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA.

Abstract

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. Dynamics of the immunological synapse: finding, establishing and solidifying a connection

2. Three-dimensional segregation of supramolecular activation clusters in T cells

3. The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

4. T Cell Receptor Signaling Precedes Immunological Synapse Formation

5. Staging and resetting T cell activation in SMACs

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