MicroRNA control of protein expression noise-Reference-Cited by-同舟云学术

MicroRNA control of protein expression noise

Published:2015-04-03 Issue:6230 Volume:348 Page:128-132
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Schmiedel Jörn M.¹²³,Klemm Sandy L.⁴,Zheng Yannan³,Sahay Apratim³,Blüthgen Nils¹²,Marks Debora S.⁵,van Oudenaarden Alexander³⁶⁷

Affiliation:

1. Integrative Research Institute for the Life Sciences and Institute for Theoretical Biology, Humboldt Universität, 10115 Berlin, Germany.

2. Institute of Pathology, Charité-Universitätsmedizin, 10117 Berlin, Germany.

3. Department of Physics, Massachusetts Institute of Technology (MIT), Cambridge MA 02139, USA.

4. Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

5. Department of Systems Biology, Harvard Medical School, Longwood Avenue, Boston, MA 02115, USA.

6. Department of Biology, MIT, Cambridge, MA 02139, USA.

7. Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, Netherlands.

Abstract

Expressing variability under miRNA control MicroRNAs (miRNAs) repress gene expression by inhibiting translation and increasing mRNA degradation. Schmiedel et al. used single-cell reporter experiments and mathematical modeling to show that miRNAs can reduce not just expression but the expression variability of target genes (see the Perspective by Hoffman and Pilpel). Combinatorial targeting principles ensured reduced variability for most miRNA gene targets. Thus, miRNAs may provide safeguards for the precision of gene expression during development or cellular homeostasis. Science , this issue p. 128 ; see also p. 41

Funder

European Molecular Biology Organization

Harvard Medical School

European Research Council

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Koch Institute for Integrative Cancer Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary