Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch-Reference-Cited by-同舟云学术

Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch

Published:2015-09-11 Issue:6253 Volume:349 Page:1216-1220
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dehorter Nathalie¹²,Ciceri Gabriele²,Bartolini Giorgia¹²,Lim Lynette¹²,del Pino Isabel¹²,Marín Oscar¹²

Affiliation:

1. MRC Centre for Developmental Neurobiology, Medical Research Council, New Hunt's House, Guy's Campus, King’s College London, London SE1 1UL, UK.

2. Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d’Alacant, Spain.

Abstract

Changing properties of interneurons Neuronal identity is determined early during development. It is assumed that once a neuron has adopted its identity, this remains stable throughout life. However, Dehorter et al. investigated the mechanisms controlling the specification of fast-spiking interneurons. They found that the transcription factor Er81 is crucial for the normal specification of these cells by regulating the expression of a potassium channel subunit. Science , this issue p. 1216

Funder

Wellcome Trust

European Research Council

Spanish Ministry of Science and Innovation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Driving fast-spiking cells induces gamma rhythm and controls sensory responses

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