Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown

Abstract

You can find your own way Migration of cells through tissues and embryos is often steered by gradients of attractive chemicals in a process called chemotaxis. Cells are best at navigating complex routes, for which they use “self-generated chemotaxis” and create their own attractant gradients. An example of this is when neutrophils migrate into tissues to attack infection. Using modeling and live-cell data, Tweedy et al. found that self-generated chemotaxis allows cells to obtain surprising amounts of information about their environment. Cells of the slime mold Dictyostelium discoideum and mouse pancreatic cancer–derived cells were able to use the diffusion of attractants to identify the best route through complex mazes, even when the correct path was long and twisted, without ever entering incorrect paths. Science , this issue p. eaay9792