Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism-Reference-Cited by-同舟云学术

Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism

Published:2007-11-23 Issue:5854 Volume:318 Page:1309-1312
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Frank Michael J.¹²³,Samanta Johan¹²³,Moustafa Ahmed A.¹²³,Sherman Scott J.¹²³

Affiliation:

1. Department of Psychology and Program in Neuroscience, University of Arizona, Tucson, AZ 85721, USA.

2. Banner Good Samaritan Medical Center, Phoenix, AZ 85004, USA.

3. Department of Neurology, University of Arizona, Tucson, AZ 85724, USA.

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. We showed that DBS selectively interferes with the normal ability to slow down when faced with decision conflict. While on DBS, patients actually sped up their decisions under high-conflict conditions. This form of impulsivity was not affected by dopaminergic medication status. Instead, medication impaired patients' ability to learn from negative decision outcomes. These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients and were predicted by a single neurocomputational model of the basal ganglia.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference37 articles.

1. Connectionist and diffusion models of reaction time.

2. The time course of perceptual choice: The leaky, competing accumulator model.

3. The physics of optimal decision making: A formal analysis of models of performance in two-alternative forced-choice tasks.

4. Rapid decision threshold modulation by reward rate in a neural network

5. Cortico–basal ganglia circuit mechanism for a decision threshold in reaction time tasks

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