Affiliation:
1. Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK.
Abstract
Cytosol,
Salmonella
, and pH
Salmonella
and other bacterial pathogens grow inside animal host cells within intracellular vacuoles. The bacteria secrete effector proteins across the vacuole membrane, altering the host-cell physiology to the pathogen's advantage. The secretion process involves a specialized secretory apparatus, the type III secretion system, whose assembly is triggered by the low pH within the host-cell vacuole. Now,
Yu
et al.
(p.
1040
, published online 15 April; see the Perspective by
Collier
) have identified neutral pH as a physiological signal for effector translocation by intracellular
Salmonella
. The process involves the disassembly of a membrane-bound regulatory complex that is also found in other animal pathogens. Thus,
Salmonella
exploits the low pH of the vacuole as a signal to induce assembly of the secretion system, and then the neutral pH of the cytoplasm to trigger effector translocation.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
157 articles.
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