Affiliation:
1. Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.
Abstract
How the ER manages mitochondrial division
It has been unclear how mitochondrial DNA (mtDNA) replication is spatially controlled in mammalian cells and how the mitochondrial nucleoid—the protein-DNA structure that is the unit of mtDNA inheritance—is distributed at the cellular level. Lewis
et al.
now show that homeostatic mtDNA synthesis in mitochondrial nucleoids in mammalian cells is spatially linked to a small subset of endoplasmic reticulum (ER)-mitochondria contact sites that are specifically destined for mitochondrial division. Successive events of mtDNA replication, mitochondrial division, and mitochondrial motility function together to ensure the accurate distribution of mtDNA in cells. Furthermore, ER-mitochondria contacts coordinate the licensing of mtDNA replication with division to distribute newly replicated nucleoids to daughter mitochondria.
Science
, this issue p.
261
Funder
NIH
NIH Ruth L. Kirschstein Postdoctoral Fellowship
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
461 articles.
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