Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"-Reference-Cited by-同舟云学术

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Published:2007-01-12 Issue:5809 Volume:315 Page:187-187
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rosskopf Dieter¹²,Bornhorst Alexa¹²,Rimmbach Christian¹²,Schwahn Christian¹²,Kayser Alexander¹²,Krüger Anne¹²,Tessmann Grietje¹²,Geissler Ingrid¹²,Kroemer Heyo K.¹²,Völzke Henry¹²

Affiliation:

1. Institute of Pharmacology, Ernst Moritz Arndt University of Greifswald, Germany.

2. Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University of Greifswald, Germany.

Abstract

Contrary to the findings of Herbert et al . (Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study. A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweight individuals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference7 articles.

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4. B. Wolff et al., J. Hypertens.23, 1361 (2005).

5. D. Yabe et al., Proc. Natl. Acad. Sci. U.S.A.100, 3155 (2003).

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