Transient compartmentalization of RNA replicators prevents extinction due to parasites-Reference-Cited by-同舟云学术

Transient compartmentalization of RNA replicators prevents extinction due to parasites

Published:2016-12-09 Issue:6317 Volume:354 Page:1293-1296
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Matsumura Shigeyoshi¹²³,Kun Ádám⁴⁵,Ryckelynck Michael²⁶,Coldren Faith²,Szilágyi András⁴⁷,Jossinet Fabrice⁶,Rick Christian²⁶,Nghe Philippe¹,Szathmáry Eörs⁴⁵⁸⁹,Griffiths Andrew D.¹²

Affiliation:

1. École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), CNRS UMR 8231, 10 Rue Vauquelin, 75231 Paris Cedex 05, France.

2. Institut de Science et d’Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg, 8 Allée Gaspard Monge, BP 70028, 67083 Strasbourg Cedex, France.

3. Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama, 930-8555, Japan.

4. Parmenides Center for the Conceptual Foundations of Science, Munich/Pullach, Germany.

5. MTA-ELTE-MTM Ecology Research Group, Budapest, Hungary.

6. Architecture et Réactivité de l’ARN, CNRS UPR 9002, Université de Strasbourg, 67084 Strasbourg, France.

7. MTA-ELTE Theoretical Biology and Evolutionary Ecology Research Group, Department of Plant Systematics, Ecology and Theoretical Biology, Budapest, Hungary.

8. Department of Plant Systematics, Ecology and Theoretical Biology, Institute of Biology, Eötvös University, Budapest, Hungary.

9. Conflict and Cooperation in Evolutionary Systems Program, Institute of Advanced Studies, Kőszeg, Hungary.

Abstract

Beating the curse of the parasite The evolution of molecular replicators was a critical step in the origin of life. Such replicators would have suffered from faster-replicating “molecular parasites” outcompeting the parental replicator. Compartmentalization of replicators inside protocells would have helped ameliorate the effect of parasites. Matsumura et al. show that transient compartmentalization in nonbiological materials is sufficient to tame the problem of parasite takeover. They analyzed viral replication in a droplet-based microfluidic system, which revealed that as long as there is selection for a functional replicator, the population is not overwhelmed by the faster-replicating parasite genomes. Science , this issue p. 1293

Funder

European Union Seventh Framework Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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