LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling-Reference-Cited by-同舟云学术

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Published:2019-05-10 Issue:6440 Volume:364 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Choi Jin Huk¹^ORCID,Zhong Xue¹^ORCID,McAlpine William¹^ORCID,Liao Tzu-Chieh¹^ORCID,Zhang Duanwu¹^ORCID,Fang Beibei¹^ORCID,Russell Jamie¹^ORCID,Ludwig Sara¹,Nair-Gill Evan¹^ORCID,Zhang Zhao¹^ORCID,Wang Kuan-wen¹,Misawa Takuma¹,Zhan Xiaoming¹^ORCID,Choi Mihwa¹,Wang Tao¹²,Li Xiaohong¹^ORCID,Tang Miao¹^ORCID,Sun Qihua¹,Yu Liyang¹^ORCID,Murray Anne R.¹^ORCID,Moresco Eva Marie Y.¹^ORCID,Beutler Bruce¹^ORCID

Affiliation:

1. Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2. Quantitative Biomedical Research Center, Department of Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Wnt signaling out on a limb The Wnt/β-catenin signaling pathway is central to hematopoietic stem cell (HSC) survival, renewal, and differentiation. Both excessive and insufficient β-catenin can have adverse consequences, so “destruction complexes” ensure its precise regulation. Using a mouse forward genetic screen, Choi et al. identified a mutation in the gene limb region 1–like ( Lmbr1l ) that severely impaired lymphocyte development and function. LMBR1L interacted with multiple members of the Wnt/β-catenin signaling pathway. The authors found that LMBR1L works with an endoplasmic reticulum–localized ubiquitin ligase to serve as a second brake on this system in lymphocytes. Deleting β-catenin decreased apoptosis and restored proliferative capacity in an Lmbr1l -deficient mouse T cell line. Science , this issue p. eaau0812

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. An HMG-box-containing T-cell factor required for thymocyte differentiation

2. Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

3. A role for Wnt signalling in self-renewal of haematopoietic stem cells

4. WNT signalling in the immune system: WNT is spreading its wings

5. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Cited by 47 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Disruption of the ZFP574–THAP12 complex suppresses B cell malignancies in mice;Proceedings of the National Academy of Sciences;2024-07-24

2. Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity;EMBO Reports;2024-07-02

3. Maternal androgen exposure induces intergenerational effects via paternal inheritance;Journal of Endocrinology;2024-05-28

4. Identification of genetic suppressors for a BSCL2 lipodystrophy pathogenic variant in Caenorhabditis elegans;Disease Models & Mechanisms;2024-04-16

5. Viable mutations of mouse midnolin suppress B cell malignancies;Journal of Experimental Medicine;2024-04-16