Affiliation:
1. Department of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Abstract
A major psychosocial stress circuit
Psychological stress induces various physiological responses by activating the sympathetic nervous system. The brain circuits involved in these functions are still not completely understood. In a rat model, Kataoka
et al.
combined anatomical tracing, immediate early gene expression analysis, pharmacology, optogenetics, electrophysiology, and genetic cell ablation to provide evidence for the prominent role of a ventral part of the medial prefrontal cortex in sympathetic responses to social defeat stress. This brain region sends excitatory projections to the dorsomedial hypothalamus as a central coordinator of the psychosocial stress responses. This pathway is crucial for understanding how psychosocial stress influences a variety of body functions.
Science
, this issue p.
1105
Funder
Takeda Science Foundation
Uehara Memorial Foundation
Japan Agency for Medical Research and Development
Brain Science Foundation
Japan Society for the Promotion of Science
Ministry of Education, Culture, Sports, Science, and Technology
Kato Memorial Bioscience Foundation
Japan Science and Technology Agency
Kowa Life Science Foundation
Ono Medical Research Foundation
Nakajima Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
95 articles.
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