Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division

Author:

Christen Matthias1,Kulasekara Hemantha D.1,Christen Beat2,Kulasekara Bridget R.3,Hoffman Lucas R.4,Miller Samuel I.15

Affiliation:

1. Department of Immunology, University of Washington, Seattle, WA 98195, USA.

2. Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.

4. Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.

5. Departments of Genome Sciences, Microbiology, and Medicine, University of Washington, Seattle, WA 98195, USA.

Abstract

Keeping Tabs on Second-Messenger Localization The prokaryotic second-messenger cyclic diguanosine monophosphate (c-di-GMP) is a global bacterial signaling molecule that controls the switch between motile or planktonic life-styles and sedentary or adhesive life-styles. Regulation by this second messenger has been associated with virulence traits, biofilm formation, and antibiotic tolerance. Christen et al. (p. 1295 ) engineered fluorescence resonance energy transfer–based sensors that enabled the visualization of c-di-GMP fluctuations in individual bacterial cells. Using the sensor, c-di-GMP distribution was found to change during the cell cycle in Caulobacter crescentus and Pseudomonas aeruginosa cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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